Impaired Gluconeogenesis in Isolated Hepatocytes from S. Pneumoniae Infected Rats: Effect of Infection on Gluconeogenesis
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
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The gluconeogenic capacity of single cell suspension of hepatocytes isolated from control and S. pneumoniae infected rats was determined. It is shown that 1 gluconeogenesis from pyruvate and lactate is reduced by 35-42 in hepatocytes isolated from agonal rats 2 addition of ethanol fails to return glucose synthesis to control levels and 3 the activity of a rate limiting gluconeogenic enzyme, phosphoenolpyruvate carboxykinase is reduced by 47 in livers of agonal rats. It is proposed that the decrease in PEPCK activity, rather than a lack of reducing equivalents may account for the agonal breakdown in glucose synthesis during severe infections.
- Medicine and Medical Research