Accession Number:

ADA043552

Title:

Impaired Gluconeogenesis in Isolated Hepatocytes from S. Pneumoniae Infected Rats: Effect of Infection on Gluconeogenesis

Descriptive Note:

Interim rept.

Corporate Author:

ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD

Personal Author(s):

Report Date:

1977-08-18

Pagination or Media Count:

19.0

Abstract:

The gluconeogenic capacity of single cell suspension of hepatocytes isolated from control and S. pneumoniae infected rats was determined. It is shown that 1 gluconeogenesis from pyruvate and lactate is reduced by 35-42 in hepatocytes isolated from agonal rats 2 addition of ethanol fails to return glucose synthesis to control levels and 3 the activity of a rate limiting gluconeogenic enzyme, phosphoenolpyruvate carboxykinase is reduced by 47 in livers of agonal rats. It is proposed that the decrease in PEPCK activity, rather than a lack of reducing equivalents may account for the agonal breakdown in glucose synthesis during severe infections.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE