Cell-Mediated Immune Responses of Guinea Pigs to an Inactivated Phase I 'Coxiella Burnetii' Vaccine.
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD
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The ability of a killed phase I Coxiella burnetii vaccine to induce cell-mediated immune CMI responses in guinea pigs was studied. Cell-mediated immune responses were assessed by the inhibition of macrophage migration IMM and lymphocyte transformation LT assays. The IMM response occurred rapidly, was detected at high levels, but was relatively short-lived. In contrast, the LT response developed more slowly, and persisted for a longer period. The vaccine given in a single dose, or two doses one week apart, protected guinea pigs from a subsequent virulent challenge.