Transmission, Control and Treatment of Infectious Diseases of Military Importance in Equatorial Asia.
Annual rept. 1 Oct 75-30 Sep 76,
INSTITUTE FOR MEDICAL RESEARCH KUALA LUMPUR (MALAYSIA)
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Studies of febrile patients in indigenous populations have shown that scrub typhus is a common, but frequently undiagnosed, cause of febrile illness. The clinical syndrome whether mild or severe, was difficult to distinguish clinically from that due to other infections. The antigenic properties of human isolates and the antibody response to infection have shown that the Karp strain group produces the preponderance of symptomatic infections in the study area. The strain activity in humans, rodents, and chiggers in selected study sites is being compared. In studies with immunosuppressants cyclophosphamide treated mice died following inoculation of a normally nonlethal strain. In a study of mammals and chiggers from a primary forest only a single specimen of a known vector of R. tsutsugamushi was collected. L.L. fletcheri and L.L. arenicola colonies infected with R. tsutsugamushi have been employed to study the effects of temperature on chigger development and transmission of the infection. Author
- Medicine and Medical Research