Dose-Response Effects of Intravenous Thiamine Hydrochloride on Pralidoxime Pharmacokinetics in Man.
Technical rept. Jan-Mar 75,
EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD
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Five subjects were given pralidoxime chloride 5 mgkg, iv alone or at the end of the first hour of a 3-hour infusion of thiamine hydrochloride 100 mghr on one occasion and 200 mghr on another. Plasma concentrations of pralidoxime were significantly higher when the oxime was given during a thiamine infusion plasma concentrations of the oxime were increased slightly more when the higher dose of thiamine was infused. Total oxime excretion was equal in the three groups, but the thiamine-treated groups excreted less oxime during the first 6 hours after drug administration. This suggests that thiamine caused higher concentrations of oxime in the blood by blocking the renal excretion of the drug.
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