Accession Number:

ADA037139

Title:

Kinetics of Neutrophil-Releasing Activity of Post-Leukopheresis Plasma.

Descriptive Note:

Annual rept. no. 1, 1 Feb 76-31 Jan 77,

Corporate Author:

LITTLE (ARTHUR D) INC CAMBRIDGE MASS DEPT OF EXPERIMENTAL HEMATOLOGY

Personal Author(s):

Report Date:

1977-03-01

Pagination or Media Count:

29.0

Abstract:

Plasma obtained from leukopheresed rats P.P.P. may be used to increase granulocyte yields in donors when given prior to leukopheresis. In these studies it appears that a the effect of injection of P.P.P. is dose-related and is not an all or none phenomenon, b the granulocytosis observed in the donor is related to the duration of pheresis for periods up to three hours, c the titer of neutrophil releasing activity is related to the duration of pheresis, d the granulocyte increments in the donor are proportional to the duration of pheresis, and e there is a good correlation between the donor post-pheresis granulocyte count, as well as the donor post-pheresis granulocyte increment to the neutrophil releasing activity of the plasma obtained from the donor. There is no relationship between the recipient pre-granulocyte count and the ability of the recipient to respond to injections of P.P.P., or the ability of groups of rats to respond to injections of P.P.P. on two successive days.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE