Topical Hazard Evaluation Program of Candidate Insect Repellent AI3-36540-a 1-(Cyclohexylcarbonyl)-2,6-Dimethylpiperidine.
Final rept. Oct 75-Dec 76,
ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD
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A hazard evaluation of AI3-36540-a was conducted using New Zealand White rabbits for skin and eye studies Hartley guinea pigs for a skin sensitization study and Sprague-Dawley, Wistar-derived rats for determination of acute oral toxicity. AI3-36540-a is a potential sensitizing chemical. Technical grade compound produced severe injury to the cornea and to the conjunctiva of the rabbit and may cause similar damage if it should accidentally enter the eye of man. Ethanol solutions of this compound caused a photochemical skin irritation reaction in rabbits and may prove to be phototoxic on the skin of man.