Accession Number:

ADA037078

Title:

Topical Hazard Evaluation Program of Candidate Insect Repellent AI3-36540-a 1-(Cyclohexylcarbonyl)-2,6-Dimethylpiperidine.

Descriptive Note:

Final rept. Oct 75-Dec 76,

Corporate Author:

ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD

Personal Author(s):

Report Date:

1977-03-11

Pagination or Media Count:

11.0

Abstract:

A hazard evaluation of AI3-36540-a was conducted using New Zealand White rabbits for skin and eye studies Hartley guinea pigs for a skin sensitization study and Sprague-Dawley, Wistar-derived rats for determination of acute oral toxicity. AI3-36540-a is a potential sensitizing chemical. Technical grade compound produced severe injury to the cornea and to the conjunctiva of the rabbit and may cause similar damage if it should accidentally enter the eye of man. Ethanol solutions of this compound caused a photochemical skin irritation reaction in rabbits and may prove to be phototoxic on the skin of man.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE