The Exotoxin of P. aeruginosa: A Proenzyme Having an Unusual Mode of Activation
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
Pagination or Media Count:
The exotoxin of Pseudomonas aerguinosa is a proenzyme possessing latent ADPR-transferase activity. Conversion to the active form can be effected by simultaneous treatment with a protein denaturant and a chemical able to split disulfide bonds. Activation results from a conformational change that exposes the previously buried active site. Proteolysis is not required.