Accession Number:

ADA036341

Title:

Immunology of Malaria.

Descriptive Note:

Final rept. 1 Jan 72-31 Aug 75,

Corporate Author:

RUSH-PRESBYTERIAN-ST LUKE'S MEDICAL CHICAGO ILL

Personal Author(s):

Report Date:

1976-12-12

Pagination or Media Count:

30.0

Abstract:

Clinical investigations were conducted to determine whether non-immune persons can be immunized against vivax or falciparum malaria after exposure to X-irradiated sporozoites of Plasmodium vivax or Plasmodium falciparum. Batches of Anopheles stephensi mosquitoes were infected with malaria and, 12 to 18 days later, they were irradiated with X-rays until they had received a dose of at least 12 Krads. The findings indicate that protection against malaria can be obtained by inoculation of human malaria sporozoites attenuated by X-irradiation. It is unclear at present whether the inoculation of larger number of sporozoites on one or two occasions might induce long-term protection against malaria. This question can be answered only when pure sporozoite preparations, free of mosquito tissue and contaminating microorganisms, become available for human evaluation.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE