Immunology of Malaria.
Final rept. 1 Jan 72-31 Aug 75,
RUSH-PRESBYTERIAN-ST LUKE'S MEDICAL CHICAGO ILL
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Clinical investigations were conducted to determine whether non-immune persons can be immunized against vivax or falciparum malaria after exposure to X-irradiated sporozoites of Plasmodium vivax or Plasmodium falciparum. Batches of Anopheles stephensi mosquitoes were infected with malaria and, 12 to 18 days later, they were irradiated with X-rays until they had received a dose of at least 12 Krads. The findings indicate that protection against malaria can be obtained by inoculation of human malaria sporozoites attenuated by X-irradiation. It is unclear at present whether the inoculation of larger number of sporozoites on one or two occasions might induce long-term protection against malaria. This question can be answered only when pure sporozoite preparations, free of mosquito tissue and contaminating microorganisms, become available for human evaluation.
- Medicine and Medical Research