Late Effects of Total-Body Roentgen Irradiation. Longevity and Incidence of Nephrosclerosis as Influenced by Partial-Body Shielding
SCHOOL OF AVIATION MEDICINE RANDOLPH AFB TX
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Two hundred forty-two female Wistar rats were observed throughout their life span following 1,000 r hypoxic total-body or partial-body irradiation. Hypoxic radiation superimposed anesthesia resulted in 67 percent 30 day mortality, compared to 9 percent mortality without anesthesia. Selection of the colony by acute postirradiation deaths did not influence the magnitude of late radiation sequelae as measured by life shortening. Growth retardation during the second postirradiation year was well correlated with life-shortening. Life-shortening was observed after partial-body irradiation to an extent approximately proportional to the weight of radiated tissue. Nephrosclerosis was not observed unless the upper abdomen was included within the radiation field. Other than nephrosclerosis, a similar incidence of disease was observed at death in control and irradiated rats whether partial-body or total-body irradiated.