A Deficiency of Hematopoietic Stem Cells in Steel Mice.
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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Steel-Dickie mice which have a genetic defect were selected for a model to determine some of the interaction of ionizing radiation with bone marrow cells. Therefore, population sizes of high self-renewal potential stem cells, i.e., colony forming units and low self-renewal potential stem cells, i.e., transient endogenous colony forming units in Steel mice and their normal congenic littermates were measured and compared. By correcting for differences in the seeding efficiency f, it was possible to demonstrate that Sl Sld mice suffer a deficiency of both stem cell populations. It is concluded that the defective stromal tissue of the Sld mouse does not support normal size stem cell populations.