Temporal Relationship of the Induction of Tolerance and Physical Dependence after Continuous Intoxication with Maximum Tolerable Doses of Ethanol in Rats.
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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In an effort to study chronic toxicity of the nervous system by chemicals, exploration of an animal model of ethanol dependence was examined. Previous work had demonstrated that physical dependence on ethanol could be induced in only a few days. The purpose of this study was to establish the existence of tolerance and to determine the rate of development of tolerance and physical dependence. These results demonstrate that when rats are treated with the maximum tolerable doses of ethanol, both tolerance and physical dependence can be induced in only a few days.