Accession Number:

ADA034918

Title:

Temporal Relationship of the Induction of Tolerance and Physical Dependence after Continuous Intoxication with Maximum Tolerable Doses of Ethanol in Rats.

Descriptive Note:

Scientific rept.,

Corporate Author:

ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD

Personal Author(s):

Report Date:

1976-09-01

Pagination or Media Count:

18.0

Abstract:

In an effort to study chronic toxicity of the nervous system by chemicals, exploration of an animal model of ethanol dependence was examined. Previous work had demonstrated that physical dependence on ethanol could be induced in only a few days. The purpose of this study was to establish the existence of tolerance and to determine the rate of development of tolerance and physical dependence. These results demonstrate that when rats are treated with the maximum tolerable doses of ethanol, both tolerance and physical dependence can be induced in only a few days.

Subject Categories:

  • Toxicology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE