'In Vitro' Inhibition of Microsomal Calcium Atpase from Eggshell Gland of Mallard Duck.
Technical rept. Feb-Mar 76,
EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD
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The results of this study have demonstrated the inhibition of Ca ATPase by DDT in an in vitro microsomal test system. Furthermore, this inhibition has been established to be competitive in nature. The results are similar to those of other investigators who showed Ca ATPase inhibition by DDE in shell gland homogenate. Previous studies have shown DDT-induced eggshell thinning to be due to decreased calcium content of eggshells. Since calcium ATPase has been shown to be associated with calcium transport in eggshell gland, the inhibition of this enzyme in vitro offers a possible explanation for DDT-induced eggshell thinning.