Accession Number:

ADA034659

Title:

The Effect of Intravenous Thiamine Hydrochloride on Pralidoxime Pharmacokinetics in Man.

Descriptive Note:

Technical rept. Aug-Sep 74,

Corporate Author:

EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Personal Author(s):

Report Date:

1976-12-01

Pagination or Media Count:

14.0

Abstract:

Six subjects were given pralidoxime chloride 2-PAMC1 5 mgkg, iv, by itself and during a 2.5-hour intravenous infusion of thiamine hydrochloride 100 mghr pralidoxime was given one hour after the infusion was started and the infusion ran 1.5 hours after pralidoxime was given. In the subjects receiving thiamine the plasma concentration of oxime was greater throughout the test period, the renal excretions and clearance of oxime were less during the first 1.5 hours, and the half-life of oxime was prolonged. These data suggest that thiamine inhibits the excretion of oxime, thus prolonging its effects.

Subject Categories:

  • Pharmacology
  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE