Effects of Glucose or Insulin on Myocardial Performance in Endotoxin Shock
OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY DEPT OF PHYSIOLOGY AND BIOPHYSICS
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The purpose of the present study was to determine the effects of glucose concentrations and insulin infusions on myocardial performance following endotoxin administration. Experiments were carried out on isolated, working canine left ventricular heart preparations exchanging blood with intact dogs. Myocardial function was evaluated following endotoxin and correlated with concentrations of glucose and effects of insulin infusion. Cardiac dysfunction occurred within 2-4 hours post-endotoxin and the degree of malfunction was not related to arterial blood glucose concentrations. Maintaining blood glucose at control, pre-shock, levels by infusion of 50 glucose did not prevent myocardial dysfunction as evidenced by elevations of left ventricular end diastolic pressure, and depressed power. Infusions of insulin reversed cardiac failure and maintained normal performance in spite of wide ranges in glucose concentration 5-120 mg. Findings suggest that myocardial dysfunction is not precipitated or enhanced by the hypoglycemia of endotoxin shock.
- Medicine and Medical Research