The Effects of Coronary Vasodilatation on Cardiac Performance during Endotoxin Shock.
OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY
Pagination or Media Count:
Studies in these laboratories have suggested that endotoxin and lowered coronary arterial perfusion pressures are detrimental to cardiac performance and lead to failure. Prevention of cardiac failure in the isolated canine heart preparation confronted with endotoxin and decreased coronary perfusion pressure was possible by perfusing these hearts with sodium nitroprusside. Prevention of failure was manifested by a lowered LVEDP Diastolic Pressure and was associated with increaed coronary flow and decreased coronary resistance with increased oxygen delivery and decreased oxygen extraction.
- Medicine and Medical Research