Experimental Septic Shock: Models and Mechanisms
OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY
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The present study was designed to develop a nonhuman primate model more relevant to the clinical entity of septic shock. Experiments were conducted on young adult baboons, unrestrained, and maintained at a light plane of pentobarbital anesthesia. Responses of animals infused with E. coli endotoxin or live E. coli organisms were evaluated during a 24-hour period or until death. Results suggest significant differences between the two shock models large dosages of endotoxin on contrast to those used in the canine species were required to elicit lethality characteristics. Hypoglycemia and hypoinsulinemia were regularly observed in live E. coli organism induced shock however, hyperglycemia was a consistent hallmark in the endotoxin infused model. Renal fibrin thrombi were presented only after E. coli administration while tubular necrosis was found following both organism and endotoxin infusions.
- Medicine and Medical Research