Protein Chemistry of Necrotic Wounds.
Final rept. 31 Oct 75-31 Oct 76,
CHILDREN'S HOSPITAL RESEARCH FOUNDATION WASHINGTON D C
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The author has successfully 1 isolated, purified and chemically characterized MIF 2 isolated, purified and characterized chemically lymphotactin and 3 isolated, purified and partially characterized a lysosomal permeability factor hitherto known as Skin Reactive Factor, and presumed to be lymphokine. The author made the fundamental discovery that the acid leukokinin system is most probably not a cathepsin D activated kinin, but rather is the result of the activity of the unrecognized cathepsin, which the author choose to call cathepsin H i.e. isoelectric point of pH 4.2.