Accession Number:

ADA031453

Title:

Isolation of Renal Membranes That Contain Kalli-Krein, Angiotensin I-Converting Enzyme (Kininase II), and Angiotensinase.

Descriptive Note:

Technical rept. no. 7, 1 Mar 75-31 May 77,

Corporate Author:

TEXAS UNIV HEALTH SCIENCE CENTER DALLAS

Report Date:

1976-10-15

Pagination or Media Count:

13.0

Abstract:

Fractions highly enriched in plasma membrane, endoplasmic reticulum, or brush border were prepared from rat kidney cortex. Kallikrein was concentrated in the plasma membrane fraction, but not in the brush border fraction. Angiotensin I-converting enzyme kininase II and angiotensinase were localized in the brush border membrane. It is suggested that kallikrein in the urine may originate from plasma membrane other than the brush border of proximal tubules and the conversion of angiotensin I and the inactivation of bradykinin and angiotensin II may occur on the lumen membrane of the proximal tubular cells. Author

Subject Categories:

  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE