A Continuous Aerosol Therapy System Utilizing a Modified Collision Nebulizer
PLUM ISLAND ANIMAL DISEASE CENTER GREENPORT NY GREENPORT United States
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A Collision nebulizer was incorporated into an exposure system to administer antiviral compounds as continuous aerosols to mice infected by influenza virus. The nebulizer was modified to control aerosol output by varying the liquid feed-rate. A multiple regression equation was developed from data obtained with uranine dye to define the aerosol concentration in the system as a function of the concentration of the test solution and the rate at which it was aerosolized. The rate of change of the concentration of the test solution due to evaporative losses was also ascertained for a 1 mlmin feed-rate over a 23.5-period of operation. Procedures are outlined for using these relationships to determine the concentration of a solution that will result in a given dose. Performance data for the drug ribavirin are presented.