Accession Number:

ADA030745

Title:

Swine Influenza Virus Vaccine: Potentiation in Rhesus Monkeys of Antibody Responses by a Nuclease Resistant Derivative of Poly I.Poly C

Descriptive Note:

Interim rept.

Corporate Author:

ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD

Personal Author(s):

• Stephen, Edward L.
• Hilmas, Duane E.
• Mangiafico, Joseph A.
• Levy, Hilton B.

Report Date:

1976-10-04

Pagination or Media Count:

10.0

Abstract:

Polyriboinosinic-polyribocytidylic acid stabilized with poly-i-lysine and carboxymethylcellulose poly ICLC enhances the antibody response in rhesus monkeys immunized with swine influenza virus subunit vaccine. Monkeys given the vaccine-adjuvant combination had earlier and significantly P 0.05 higher titers by 14 days.

Descriptors:

• *INFLUENZA VIRUS
• *VACCINES
• *SWINE INFLUENZA VIRUS
• RHESUS MONKEYS
• YOUTH
• SYNERGISM
• INTERFERON
• ANTIBODIES

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE