Reaction of Squirrel Monkeys to Intratracheal Inoculation with Influenza/A/New Jersey/76 (Swine) Virus
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD FORT DETRICK
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To determine whether a model could be established for laboratory investigations, 9 squirrel monkeys were inoculated intratracheally with 10 to the 7th power EID 50 of influenza virus type ANew Jersey876 Hswl N1 swine influenza virus. They responded with clinically detectable illness including fever, leukopenia, decreased food consumption, increased respiratory rate, occasional coughing, labored breathing, nasal discharge and lethargy. Convalescence was well advanced by the tenth day. All monkeys excreted virus for 7-8 days. A scoring procedure illness score has been developed for use in studies of vaccine and chemotherapeutic efficacy.
- Medicine and Medical Research