Accession Number:

ADA030248

Title:

Behavioral and Biochemical Effects Of Malathion.

Descriptive Note:

Rept for Oct 75-Apr 76,

Corporate Author:

ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD

Personal Author(s):

Report Date:

1976-09-03

Pagination or Media Count:

17.0

Abstract:

Rat conditioned avoidance performance and spontaneous motor activity were examined after intraperitoneal injection with 25, 50, 100 or 150 mgkg of the organophosphate insecticide, malathion. The effects of these dosages on plasma, erythrocyte, and brain cholinesterase activity were also assessed. Avoidance performance was significantly impaired 1 hour after injection with 50 mgkg although blood and brain cholinesterase activity remained at greater than 90 percent of control values. The higher dosages 100 and 150 mgkg produced significant decreases in blood and brain cholinesterase activity as well as avoidance performance. Spontaneous motor activity was not significantly changed at any dosage. The results suggest that low dosages of malathion may disrupt behavior without significantly reducing cholinesterase activity. Author

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE