Immunity in Chagas' Disease.
Final rept. Sep 73-May 76,
GORGAS MEMORIAL LAB BALBOA HEIGHTS CANAL ZONE
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This is the final report on the immunity in Chagas disease contract and it summarizes the results of a diversity of studies directed toward understanding the immunology of this dreaded affliction. Among the achievements mentioned are the development of a culture system which provides infective form Trypanosoma cruzi for immunology studies and the use of these infective forms in the development of a sensitive specific, indirect immunofluorescent antibody test for Chagas disease. Also mentioned are the facts that the cell membranes of live trypomastigotes are not immunoreactive with the humoral immune response of an infected host and that suppression of parasitemias in chronic Chagas disease is probably a function of the cell immune system of the host. Author
- Medicine and Medical Research