Effect of Monomethylhydrazine on Glucose Levels in Rats
Technical rept. Aug 1974-Feb 1976
AIR FORCE AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OH
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Exposure to monomethylhydrazine MMH is known to affect glucose metabolism in rats although the exact mechanism is not known and reports in the literature reflect a wide disparity in experimental results. The variety of experimental conditions that were utilized could explain, at least in part, the differences in the results reported. Some of the factors that could affect glucose response to MMH were the mode of exposure, length of exposure, anesthesia used, the convulsigenic action of MMH, and the amount of liver glycogen stores prior to exposure. The series of experiments reported here were performed to determine the influence of various experimental parameters on the glucose response to MMH exposure. Anesthesia was not required and all MMH exposures were below convulsigenic levels cancelling the effects of these two parameters. MMH was given in a single intraperitoneal injection and by intravenous infusion over a period of time. Both methods of exposure produced a hyperglycemic response but the response occurred at lower exposure levels when the MMH was continuously infused. All groups of rats that had been either fed or fasted to deplete liver glycogen showed a similar hyperglycemia although the degree of response differed.