Interferon Induction in Cynomolgus and Rhesus Monkeys Following Repeated Doses of a Modified Polyriboinosinic-Polyribocytidylic Acid Complex.
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD
Pagination or Media Count:
Serum interferon activity was determined in 12 cynomolgus and 12 rhesus monkeys injected intravenously once daily for 10 days with from 0.1 to 6.0 mgkg of a stabilized poly I.poly C complex, composed of polyriboinosinic-polyribocytidylic acid, poly-l-lysine and carboxymethylcellulose poly ICLC. Interferon activity was detected 2 h after the first injection, with maximum activity occurring 8 h after the second injection. A period of hyporesponsiveness occurred after the third injection of poly ICLC in all monkeys, and lasted until the sixth injection in the rhesus monkeys when interferon activity again became more elevated. The delayed rebound was not as apparent in cynomolgus monkeys. Rhesus monkeys injected with 6 mgkg did not exhibit serious side effects. Author