Accession Number:

ADA028604

Title:

Effects of Exogenous Fatty Acids on Growth and Enterotoxin B Formation by 'Staphylococcus aureus' 14458 and Its Membrane Mutant.

Descriptive Note:

Interim rept.,

Corporate Author:

ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD

Personal Author(s):

Report Date:

1976-08-16

Pagination or Media Count:

36.0

Abstract:

Growth and enterotoxin B SEB formation by Staphylococcus aureus 14458 and its membrane mutant can be depressed or stimulated by addition of graded amounts of saturated or unsaturated fatty acid mixtures. Under some conditions depression of SEB formation is separable from growth inhibition. Individual fatty acids most active in altering growth andor SEB production have been identified. Small amounts of unsaturated fatty acid mixture not only antagonize some effects of saturated fatty acid mixtures, but also appear to potentiate inhibition of growth and SEB formation by the saturated fatty acid mixture 2-Adamantanone, a compound which increases cell membrane fluidity, strongly suppresses SEB formation while stimulating growth. The results are discussed in relation to possible effects of exogenous fatty acids on the composition of membrane phospholipids and attendant changes in SEB production. Author

Subject Categories:

  • Microbiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE