Comparison of Cardiorenal Functions between Man and the Rhesus Monkey.
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD
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Using our recently published data for conscious and chaired rhesus monkeys, selected cardiorenal functions were compared to well established base-line values for human subjects. When data are compared directly, the following variables reveal few differences extraction ratio of PAH, renal arteriovenous O2 difference, renal portion of total O2 consumption, and CPAHTmPAH. Values for cardiac work, Cin, and TRBF are similar between macaques and man when expressed with corrections for body surface areas. When values are calculated in terms of body weights, there is no apparent difference in cardiac work. Since major cardiorenal functions show different values between man and rhesus monkeys, differences between species and conditions of measurement do not allow all experimental results from the rhesus monkeys to be extrapolated to man.
- Anatomy and Physiology