Accession Number:

ADA028350

Title:

Behavioral Effects of Delta-9-Tetrahydrocannabinol Under Hyperbaric Air.

Descriptive Note:

Medical research progress rept.,

Corporate Author:

NAVAL MEDICAL RESEARCH INST BETHESDA MD

Personal Author(s):

Report Date:

1976-01-01

Pagination or Media Count:

5.0

Abstract:

As part of a continuing research program investigating drugs that may be used in hyperbaric conditions, the present study was undertaken to determine the behavioral effects of delta-9-tetrahydrocannabinol, the main psychoactive ingredient of marijuana. Operant techniques were used to establish sensitive baseline patterns of behavior in rats. Dose-response curves were determined for 0.5, 1.0, 2.0, and 4.0 mgkg at 1, 3, 5, and 7 ATA with the animals breathing compressed air. As expected, dose-dependent decrements in performance were observed at 1-ATA conditions. Under the elevated pressure conditions, however, a reversal of behavioral toxicity occurred, where performance at 5 and 7 ATA was improved over that at surface with equivalent doses of the drug. These data suggest that the pressure reversals of anesthetics and analgesics that are reported at much greater pressures may well be detected at lower levels of pressure if more sensitive measures are utilized.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE