Accession Number:

ADA028201

Title:

Changes in the Levels of Cyclic AMP and Cyclic GMP in Gingiva and Alveolar Bone during Periodontal Surgery.

Descriptive Note:

Rept. for 5 Jul 74-25 Jul 76,

Corporate Author:

ARMY INST OF DENTAL RESEARCH WASHINGTON D C

Personal Author(s):

Report Date:

1976-07-26

Pagination or Media Count:

30.0

Abstract:

The basal levels of the nucleotides cAMP and cGMP, which have been suggested as the mediators of a number of cellular functions such as fibroblast growth and inflammation were determined in the gingiva and alveolar bone of 9 Rhesus monkeys. In addition the effects on tissue nucleotide levels that reflection of full thickness gingival flaps used as a model of wound exposure for 30,60 and 120 minutes was determined. The only significant change in tissue nucleotide levels that occurred after surgery and wound exposure was in the cAMP content of the gingiva. The levels of cAMP in the gingiva showed a progressive decline with the duration of the wound exposure.

Subject Categories:

  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE