Changes in the Levels of Cyclic AMP and Cyclic GMP in Gingiva and Alveolar Bone during Periodontal Surgery.
Rept. for 5 Jul 74-25 Jul 76,
ARMY INST OF DENTAL RESEARCH WASHINGTON D C
Pagination or Media Count:
The basal levels of the nucleotides cAMP and cGMP, which have been suggested as the mediators of a number of cellular functions such as fibroblast growth and inflammation were determined in the gingiva and alveolar bone of 9 Rhesus monkeys. In addition the effects on tissue nucleotide levels that reflection of full thickness gingival flaps used as a model of wound exposure for 30,60 and 120 minutes was determined. The only significant change in tissue nucleotide levels that occurred after surgery and wound exposure was in the cAMP content of the gingiva. The levels of cAMP in the gingiva showed a progressive decline with the duration of the wound exposure.