Cholinergic Systems in Brain Mediating Thermoregulatory Function: A Review.
EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD
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The report consists of a comprehensive review of the literature pertaining to the involvement in thermoregulatory function of cholinergic systems in the brain. The literature surveyed includes that published prior to November 1974. The review is organized into subsections, each devoted to data derived from a particular mammalian species mouse, rat, cat, rabbit, goat, sheep, rhesus monkey, man. Emphasis is placed upon evidence arising from use of the intracerebro-ventricular and intracerebral routes of drug administration, although results based on the systemic administration of centrally active modifiers of cholinergic function are also considered. The experimental findings discussed most extensively are those illustrating cholinergically mediated effects on deep body temperature, on the setpoint for thermoregulation, and on the state of activation of individual peripheral effector mechanisms mediating heat gain and heat loss.
- Anatomy and Physiology