Effects of Chronic Inhalation of Propylene Glycol 1,2-Dinitrate on the Conditioned Avoidance behavior of Primates
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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Four primates Macaca mulatta were trained to stable levels of performance on a multiple avoidance schedule of reinforcement. The schedule included alternating sessions of discrete trial cued avoidance and free operant avoidance, separated by 3-minute rest periods. Two of the animals were exposed to successive atmospheric concentrations of propylene glycol 1,2-dinitrate PGDN vapors of 1.8, 5.6, 11.0, and 28.2 mgcu. m. Exposure occurred on a 23- hour per day basis in a Rochester-type inhalation chamber at the Navy Toxicology Unit. Consecutive exposures lasted 35, 56, 20 and 14 days respectively. The other two animals were housed in an identical inhalation chamber but remained in a normal atmosphere for the duration of the testing period. These animals served as controls. Plasma concentrations of PGDN appeared to increase each time the chamber concentration was increased, however none of the four PGDN concentrations had a discernible effect on avoidance behavior. There was no measurable change in the overall behavior of either test animal which could have been attributed to general debilitation, sensory deficit, or motor dysfunction.
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