Adjuvant Effects on Immune Responses to Biologic Agents.
Annual progress rept. 1 Jul 75-30 Jun 76,
JOHNS HOPKINS UNIV BALTIMORE MD SCHOOL OF MEDICINE
Pagination or Media Count:
Morphologic, immunologic and radiokinetic findings in experimental animals are described which provide new insight into the regulation of cellular traffic in peripheral lymph nodes and the spleen. The demonstration that adjuvants disrupt normal traffic patterns and cause microvascular and parenchymal changes which retain recirculating lymphocytes within the stimulated organ provides one biological mechanism for augmenting immune responses. Conversely, metabolites of some antimicrobial drugs may suppress immune reactions by inhibiting cellular proliferation or lymphokine release.
- Anatomy and Physiology