Accession Number:

ADA026417

Title:

Mechanisms and Treatment of Lung Lesions and Associated Surfactant Damage in Shock

Descriptive Note:

Annual progress rept. no. 16, Jun 1974-Sep 1975

Corporate Author:

STRITCH SCHOOL OF MEDICINE MAYWOOD IL

Personal Author(s):

Report Date:

1975-09-18

Pagination or Media Count:

44.0

Abstract:

Purification and biochemical evaluation of the alveolar and intracellular surfactant has already been performed in two pairs of monkeys. One monkey from each pair was infused with 10 mg endotoxinkghr while the other monkey received Ringers lactate solution only. Evaluation of the intracellular surfactant failed to demonstrate differences in the biochemical composition of surfactant between control and experimental groups. Using the method of total lung fixation which was found to preserve the surfactant layer and the overall lung architecture it was demonstrated that congestive atelectasis is characterized by multifocal foldings of the alveolar walls which characteristically involve damaged areas of the injury sensitive type I epithelium. Coagulation and other hematologic changes in endotoxin shock with or without steroid treatment were recorded and the effect of epsilon aminocaproicacid EACA and trasylol on endotoxin shock was noted.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE