Accession Number:

ADA026158

Title:

First Successful Use of a Chemical Compound for the Prophylaxis and Treatment of a Lethal, Systemic, Viral Infection Common to Man and Subhuman Primates

Descriptive Note:

Technical Report

Corporate Author:

ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD FORT DETRICK

Personal Author(s):

• Stephen,Edward L.

Report Date:

1976-01-01

Pagination or Media Count:

9.0

Abstract:

PIC-L is effective for the prophylaxis and early treatment of yellow fever virus infection of monkeys. Its importance is emphasized by the potentially overwhelming challenge dose used in the present studies. The demonstrated efficacy of this new interferon inducer should prove valuable for the control of other virus diseases caused by interferon-sensitive viruses for which no effective vaccines exist. PIC-L does not completely inhibit virus replication, and therefore possesses an important attribute of an ideal antiviral drug--it is not immunosuppressive.

Descriptors:

• ANTIVIRAL AGENTS
• YELLOW FEVER
• THERAPY
• ANTIBODIES
• INTERFERON
• MONKEYS
• virus diseases
• drugs

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE