Accession Number:

ADA026064

Title:

Multiple Leukocytic Factors that Induce Reactions Characteristic of the Inflammatory Response,

Descriptive Note:

Corporate Author:

ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD

Personal Author(s):

• Mapes,Carol A.
• Sobocinski,Philip Z.

Report Date:

1976-01-01

Pagination or Media Count:

15.0

Abstract:

It is well documented that phagocytic cells of the body initiate of a hormone-like signal mechanism that induces numerous biochemical alterations characteristic of the inflammatory response. Generation of the signal mechanism requires stimulation of the cells either in vivo or in vitro by various agents which include microorganisms, toxins, or phlogistic compounds. The signal consists of endogenous mediator substances that effects alterations in plasma levels of trace metals, acute-phase globulins, pancreatic hormones, hepatic uptake of amino acids, and body temperature. Many of these alterations which occur in man during infectious illness also can be elicited in the experimental rat model by administration of substances elaborated from stimulated rabbit polymorphonuclear leukocytes PMN.

Descriptors:

• *INFLAMMATION
• *LEUKOCYTES
• RATS
• CHEMICAL PROPERTIES
• ZINC
• AMINO ACIDS
• TRACE ELEMENTS
• RABBITS
• PHAGOCYTES

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE