Accession Number:

ADA025995

Title:

Experimental Scrub Typhus Immunogens,

Descriptive Note:

Corporate Author:

WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

Report Date:

1976-01-01

Pagination or Media Count:

10.0

Abstract:

This study arose from the conviction that an alternate method of rickettsial inactivation was requires. New data suggested that cell-mediated immunity CMI, rather than antibody, was required for heterologous protection. Since the penetration of mammalian cells by rickettsiae requires active rickettsial metabolism, it was felt that radiation might be a tool that could be used to produce a non-replicating immunogen capable of infecting at the cellular level and possibly eliciting a cell-mediated immune response. Gamma radiation was chosen because it is more penetrating than ultraviolet radiation, thereby being more suitable for processing large volumes of immunogen.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE