Experimental Scrub Typhus Immunogens,
WALTER REED ARMY INST OF RESEARCH WASHINGTON D C
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This study arose from the conviction that an alternate method of rickettsial inactivation was requires. New data suggested that cell-mediated immunity CMI, rather than antibody, was required for heterologous protection. Since the penetration of mammalian cells by rickettsiae requires active rickettsial metabolism, it was felt that radiation might be a tool that could be used to produce a non-replicating immunogen capable of infecting at the cellular level and possibly eliciting a cell-mediated immune response. Gamma radiation was chosen because it is more penetrating than ultraviolet radiation, thereby being more suitable for processing large volumes of immunogen.
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