Studies on the Antigenic Composition of 'Coxiella Burnetii'.
Annual progress rept. 1 Jul 75-30 Jun 76,
WASHINGTON STATE UNIV PULLMAN
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Immunization with C. burnetii ellicites or cell-mediated immunity. The development of this immunity may remain compartmentalized and lack systemic expression. This is observed especially in animals immunized by the intranasal route and is true for lymphocyte transformation as well as migration inhibition assays. The expression of this cell-mediated immunity would appear vital to control of C. burnetii since in vitro analysis indicates no direct role for antibody in control of intracellular rickettsial parasitism. However, macrophages, in vitro, can be activated by the products released following lymphocyte-antigen or lymphocyte-mitogen interaction. Author
- Medicine and Medical Research