Biochemical Changes in Tissues During Infectious Illness: The Bioenergetics of Infection and Exercise.
Annual progress rept. no. 11, 1 Jul 75-30 Jun 76,
RUTGERS - THE STATE UNIV NEW BRUNSWICK N J
Pagination or Media Count:
A new modification of the Squibb, Solotorovsky, Beisel energy model has been developed which makes possible high levels of voluntary exercise in rats or chicks over a 12-day experimental period, thus covering the various stages of most disease cycles. In addition, it is now possible to simultaneously determine the daily energy requirements of such interactions. Data gathered as a result of this methodology show that energy demands increase as a result of encephalomyocarditis and Salmonella typhimurium infections in rats given voluntary access to running wheels. The energy needs were additive, indicating different pathways of utilization. Animals inoculated with encephalomyocarditis went from hyper to hypoactive states following inoculation the reverse effect was noted in S. typhimurium infected rats. Nephrectomized weanling rats exercised less than controls and sham operated rats but required significantly more energy. On day 9 of the trial nephrectomy greatly increased hyperactivity, which was speculated to be correlated with increased uremia.