Intestinal Colonization by Enterotoxigenic 'Escherichia coli'.
Annual rept. no. 1, 1 Sep 74-30 Sep 75,
IOWA STATE UNIV AMES DEPT OF PATHOLOGY
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Intestinal colonization by adhesion to mucosa is a general characteristic of enteropathogenic E. coli and not a characteristic only of strains which carry the K88 antigen. Jejunal colonization is not a prerequisite for the production of severe diarrheal disease by enteropathogenic E. coli. ileal colonization will suffice, and some strains characteristically colonize ileum and not jejunum. Polysaccharide K antigens of enteropathogenic E. coli are not required for intestinal colonization although they may contribute to this attribute of some strains. There is evidence that pili confer the intestinal adhesive and colonizing attributes of several strains of enteropathogenic E. coli. Mitomycin C greatly enhances the synthesis of heat labile enterotoxin in vitro by several porcine strains of enteropathogenic E. coli. Author
- Medicine and Medical Research