The Acute and Chronic Biochemical and Behavioral Effects of Cyclotrimethylenetrinitramine
MARYLAND UNIV BALTIMORE SCHOOL OF PHARMACY
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The overall objective of this project was to determine if trimethylenetrinitramine, a central excitatory agent, induces changes in behavior, in brain metabolism and in neurotransmitters. This objective was approached through a comparison of doses and time relationships between changes in biochemical parameters and changes in behavioral measures of brain activity. This report presents the results of studies designed to 1 Establish the effect of trimethylenetrinitramine on oxygen uptake and determine the effect on two specific brain enzyme systems, brain cholinesterase and monoamine oxidase. 2 Establish the effect of trimethylenetrinitramine on steady state levels and turnover rates of brain norepinephrine, dopamine, 5-hydroxytryptamine and possible gama-aminobutyric acid GABA.