Intestinal Physiology Studies. Absorption and Metabolism of Fat.
Final rept. 1 Feb 68-30 Nov 70,
TUFTS UNIV BOSTON MASS SCHOOL OF MEDICINE
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The following topics are discussed in this article 1 The mechanism of fat malabsorption in patients with alcoholic cirrhosis. The present study demonstrated that there is a mucosal factor in the cirrhotics since long chain fatty acids were absorbed at a slower rate in isolated jejunal segments of cirrhotic patients as compared to healthy volunteers. 2 Effect of an inhibitor of alkaline phosphatase in lipid absorption. The present study was undertaken to test the hypothesis that an inhibitor of intestinal alkaline phosphatase may affect lipid absorption. Rates of absorption of the oleic acid decreased significantly when the inhibitor was added to the perfusate. 3 The effect of carbon chain length of perfused fatty acids on the alkaline phosphatases of the rat small bowel mucosa. The observations suggest a possible role of intestinal alkaline phosphatase in the mucosal transport of long chain fatty acids. 4 Effect of medium chain triglycerides MCT on fatty acid chain length of hepatic triglycerides in man. MCT feeding induced a significant difference in the composition of the liver lipids in patients with alcoholic cirrhosis and 5 The origin of fat in chylous ascites of patients with cirrhosis. Studies with labelled medium and long chain lipids suggested leakage of small quantities of small chylomicrons from the intestinal lymphatics in patients with nonchylous ascites and of large quantities of all size chylomicrons in cirrhotic patients with chylous ascites.
- Medicine and Medical Research