Delineation of Immunogenic Regions by Tolerance Induction.
Final rept. 1 Mar 72-31 Dec 75,
WAYNE STATE UNIV DETROIT MICH DEPT OF IMMUNOLOGY AND MICROBIOLOGY
Pagination or Media Count:
Delineation of the portions of an anitgen which react with antibody is of importance in vaccine design and in combating allergic phenomena. These regions of a model antigen, oxidized ribonuclease, were mapped in a genetically pure line of mice BALBc using a number of natural and synthetic fragments and a variety of immunological technics. Procedures for suppressing the immune response to oxidized ribonuclease were developed. Intact antigen or a peptide from the carboxyterminal region containing 20 amino acid residues given prior to or at the time of immunization suppressed the immune response. It is not clear whether the fragments suppressed antibody formation to only its own region or to the entire molecule.
- Medicine and Medical Research