Accession Number:

ADA024165

Title:

Effects of Exposure to Monomethylhydrazine and 1,1-Dimethylhydrazine on the Immunological Responsiveness of Guinea Pigs

Descriptive Note:

Final rept. Jun 1974-Sep 1975

Corporate Author:

AIR FORCE AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OH

Personal Author(s):

Report Date:

1976-02-01

Pagination or Media Count:

13.0

Abstract:

The humoral immune response of guinea pigs was measured by determining serum antibody titers to bovine serum albumin. Cell mediated immunity was tested in vivo by evaluating the delayed hypersensitivity to tuberculin. Three compounds were tested. One, 6-mercaptopurine 6MP, was a known immunosuppressive drug. Its administration resulted in significantly depressed humoral and cellular responses, demonstrating that these methods could be used to evaluate immunosuppression in routine toxicity testing. Exposure to the two toxic rocket propellants monomethylhydrazine and 1,1-dimethylhydrazine resulted in a similar but less pronounced decrease in immune responsiveness.

Subject Categories:

  • Liquid Rocket Propellants
  • Environmental Health and Safety

Distribution Statement:

APPROVED FOR PUBLIC RELEASE