Accession Number:

ADA024098

Title:

Effects of CNS Manipulations on Seizure Latency Following Monomethylhydrazine Administration in the Cat

Descriptive Note:

Final rept.

Corporate Author:

CALIFORNIA UNIV LOS ANGELES SCHOOL OF MEDICINE

Report Date:

1976-01-01

Pagination or Media Count:

10.0

Abstract:

The objective of this study was to determine the influence of intracranial electrode placement upon the seizure response to monomethylhydrazine, and to replicate previous findings on the effects of EEG operant conditioning on this response. Thirty cats were studied, 10 in each of 3 different experimental groups. The dependent variable was latency in minutes to generalized motor seizures. The three experimental groups were 1 an unoperated group, 2 an operated group with cortical and subcortical electrodes, and 3 an operated group as in 2, but provided additionally with sensorimotor rhythm SMR EEG operant conditioning. The findings suggested that 1 some aspect of the procedure associated with central nervous system electrode implantation increased susceptibility to MMH-induced seizures, 2 unoperated animals had individual differences in seizure susceptibility, but were significantly more resistant to MMH toxicity than operated animals, and 3 SMR-trained operated animals had individual differences in response to training, but were also more resistant to MMH toxicity.

Subject Categories:

  • Medicine and Medical Research
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE