Depletion of Cardiac Norepinephrine during Two Forms of Hemolytic Anemia in the Rat.
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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Rats were treated with phenylhydrazine. Following the rapid onset of anemia, there was a loss of 60 percent of the stored norepinephrine in the heart within 48 hours of treatment. Associated with the loss of cardiac norepinephrine was an increase in the wet weight of the heart, reaching 40 percent above control 48 hours after treatment. Phenylhydrazine itself probably does not directly mediate this depletion since the vas deferens, brain and spleen have a normal store of norepinephrine at 48 hours. Anemia was also induced by treating rats with antirat red blood cell serum. The hearts of these rats were also depleted of norepinephrine. These experiments show that during two forms of anemia there is a loss of norepinephrine from the sympathetic neurons innervating the heart.
- Medicine and Medical Research