Accession Number:

ADA024095

Title:

Iodinated Bleomycin: An Unsatisfactory Radiopharmaceutical for Tumor Localization.

Descriptive Note:

Scientific rept.,

Corporate Author:

ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD

Report Date:

1976-03-01

Pagination or Media Count:

14.0

Abstract:

Cobalt-57 bleomycin is a clinically useful tumor localizing agent, but attempts to label bleomycin BLEO with other radionuclides have been made because of the long physical half-life of Co57. As an alternative labeling approach, BLEO was iodinated both directly on the imidazole ring and indirectly by reaction with N-succinimidyl 3-4-hydroxy, 3-iodophenyl propionate. Directly iodinated BLEO retained antibacterial activity, but in tumor-bearing rats showed a lower tumor to blood ratio at 2 hours 2.3 than was obtained with Co57 BLEO 11.8. The antibacterial activity of the indirectly labeled BLEO was markedly reduced and this material showed a tumor to blood ratio at 2 hours of 0.55.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE