Further Studies in Spinal Cord Autoregulation.
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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Using the hydrogen clearance method to measure focal spinal cord blood flow SCBF in the rhesus monkey Macaca mulatta, the effect of high cervical cord section on the phenomenon of autoregulation was studied. Laminectomies were performed at the T7-T11 as well as the C1-C2 levels. The spinal cord was completely severed at C1-C2. Under normocapnic conditions, SCBF was then measured in the thoracic spinal cord over a wide range of mean arterial blood pressures MAP. The MAP was either lowered by bleeding or raised by the intravenous infusion of norepinephrine. Autoregulation was found to be intact between 50 and 125 mm Hg, following a pattern similar to the one observed in the intact animal. Author
- Medicine and Medical Research