Accession Number:

ADA024090

Title:

Hyperemia and Edema in the Monkey Spinal Cord Following Injury: Modified by Histamine Antagonists.

Descriptive Note:

Scientific rept.,

Corporate Author:

ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD

Report Date:

1976-03-01

Pagination or Media Count:

15.0

Abstract:

Using the hydrogen washout technique, blood flow in the lateral funiculus of the spinal cord of rhesus monkeys was measured before and after a contusion sufficient to render the animals paraplegic. In untreated animals, the blood flow increased 1 hour after injury to almost twice the normal flow rate 17.6 to 31.8 mlmin per 100 g. When the animals were pretreated with histamine antagonists chlorpheniramine, an H sub 1 antagonist, and metiamide, an H sub 2 antagonist, there was no significant increase in blood flow following contusion. Antihistamines were ineffective in preventing edema. Author

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE