Naphthyridine Antimalarial Agents
Final technical rept. 1 Apr 1973-30 Jun 1975
EXXON RESEARCH AND ENGINEERING CO LINDEN NJ GOVERNMENT RESEARCH LAB
Pagination or Media Count:
Interest in the 4-amino-1,5-naphthyridines as potential prophylactic antimalarial agents has been generated by the structural similarity of the ring system to both the 4- and 8-aminoquinolines. In synthetic studies during the program, the authors sought to expand upon the derivatives of 4-amino-1,5-naphthyridine which are currently available in an effort to secure an optimal prophylactic antimalarial drug. Accordingly, as a result of the synthetic efforts, a total of 26 naphthyridine target and 145 naphthyridine intermediates and miscellaneous precursors have been prepared and submitted for biological testing. While antimalarial testing has not yet been completed, results obtained for most of the target drugs submitted to WRAIR have disclosed no significant prophylactic activity in the lower dosage range.
- Organic Chemistry