Korean Hemorrhagic Fever.
KOREA UNIV SEOUL COLL OF MEDICINE
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This report is a summary of history of korean hemorrehagic fever KHF. The outbreak had been localized in the vicinity of the DMZ until 1970. Since 1971 the disease has invaded the southern areas of the Korean pennisula. In 1975, KHF cases admitted to hospitals were 610 with 6.5 fatality 370 Korean army personnel, 239 civilians and 1 American soldier. In quantitative analysis of immunoglobulin of KHF patients serums, IgM increased significantly until 20 days after onset of fever, then decreased gradually. IgG increased until 30 days after onset then decreased slowly. Levels of C3 were elevated above normal range by 2 weeks after onset then began to decrease. Specific antigens to KHF convalescent serum were demonstrated in lungs and kidneys of Apodemus agrarius coreae collected in endemic foci of KHF. 32 out of 1,337 tissues tested proved to have specific antigens to KHF convalescent serums. Antigens to KHF are specific to KHF convalescent serums. Neutralizing antibodies in patients serums are increased remarkably during the course of illness. Author
- Medicine and Medical Research